Drug interactions
Citalopram + Eliglustat
Severity: Major
Citalopram and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and citalopram prolongs QTc. The combination could raise the risk of arrhythmia, particularly in patients with cardiac disease.
What this interaction means in plain words
Citalopram and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Additive QTc prolongation; citalopram's CYP2D6 inhibition is weak but may modestly raise eliglustat levels.
What to do
Avoid in patients with cardiac disease or a long QT. Otherwise check ECG and electrolytes and monitor closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Citalopram with Eliglustat?
MediHelp rates the interaction as major. Citalopram and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and citalopram prolongs QTc. The combination could raise the risk of arrhythmia, particularly in patients with cardiac disease.
How serious is the interaction between Citalopram and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with cardiac disease or a long QT. Otherwise check ECG and electrolytes and monitor closely.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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