Drug interactions
Citalopram + Eslicarbazepine
Severity: Moderate
Citalopram and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19 and can raise citalopram concentrations, increasing dose-related adverse effects including QT prolongation. It also induces CYP3A4, but the net effect is likely an increase.
What this interaction means in plain words
Citalopram and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine inhibits CYP2C19, reducing citalopram metabolism.
What to do
Monitor for citalopram adverse effects and consider ECG monitoring in at-risk patients. Reduce the citalopram dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Citalopram with Eslicarbazepine?
MediHelp rates the interaction as moderate. Citalopram and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19 and can raise citalopram concentrations, increasing dose-related adverse effects including QT prolongation. It also induces CYP3A4, but the net effect is likely an increase.
How serious is the interaction between Citalopram and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects and consider ECG monitoring in at-risk patients. Reduce the citalopram dose if needed.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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