Drug interactions
Citalopram + Etravirine
Severity: Moderate
Citalopram and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and inhibits CYP2C19, both involved in citalopram metabolism, so the net effect on citalopram levels is uncertain. Reduced efficacy or increased adverse effects could occur.
What this interaction means in plain words
Citalopram and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and inhibits CYP2C19, altering citalopram clearance.
What to do
Monitor antidepressant response and tolerability after starting or stopping etravirine, and adjust the citalopram dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Citalopram with Etravirine?
MediHelp rates the interaction as moderate. Citalopram and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and inhibits CYP2C19, both involved in citalopram metabolism, so the net effect on citalopram levels is uncertain. Reduced efficacy or increased adverse effects could occur.
How serious is the interaction between Citalopram and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tolerability after starting or stopping etravirine, and adjust the citalopram dose as needed.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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