Drug interactions
Citalopram + Gilteritinib
Severity: Major
Citalopram and Gilteritinib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use raises the risk of serious ventricular arrhythmia. Citalopram may additionally interfere with gilteritinib activity through serotonin or sigma receptor interactions, which could theoretically reduce its efficacy.
What this interaction means in plain words
Citalopram and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation; possible pharmacodynamic antagonism via 5-HT2B or sigma receptor binding.
What to do
Prefer an alternative antidepressant during gilteritinib therapy. If both are required, monitor ECG and electrolytes regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Citalopram with Gilteritinib?
MediHelp rates the interaction as major. Citalopram and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so combined use raises the risk of serious ventricular arrhythmia. Citalopram may additionally interfere with gilteritinib activity through serotonin or sigma receptor interactions, which could theoretically reduce its efficacy.
How serious is the interaction between Citalopram and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antidepressant during gilteritinib therapy. If both are required, monitor ECG and electrolytes regularly.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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