Drug interactions
Citalopram + Hydrochlorothiazide-lisinopril
Severity: Moderate
Citalopram and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both SSRIs and thiazide diuretics can cause hyponatremia, and the risk is greater in older adults. Thiazide-induced hypokalemia and hypomagnesemia may also add to citalopram's QT effect.
What this interaction means in plain words
Citalopram and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive hyponatremia via SIADH from the SSRI and renal sodium loss from the thiazide, plus electrolyte-related QT risk.
What to do
Check serum sodium, potassium and magnesium at baseline and after initiation, especially in elderly patients. Evaluate for confusion, nausea or falls and consider an ECG if electrolytes are abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Citalopram and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both SSRIs and thiazide diuretics can cause hyponatremia, and the risk is greater in older adults. Thiazide-induced hypokalemia and hypomagnesemia may also add to citalopram's QT effect.
How serious is the interaction between Citalopram and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium, potassium and magnesium at baseline and after initiation, especially in elderly patients. Evaluate for confusion, nausea or falls and consider an ECG if electrolytes are abnormal.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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