Drug interactions
Citalopram + Letermovir
Severity: Minor
Citalopram and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may increase citalopram exposure; its effect on CYP2C19 is opposite (induction), so net effect is uncertain. Higher citalopram levels could raise QT and adverse effect risk.
What this interaction means in plain words
Citalopram and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4 but induces CYP2C19, giving an uncertain net effect on citalopram clearance.
What to do
Monitor for citalopram adverse effects or loss of efficacy during letermovir therapy. Consider an ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Citalopram with Letermovir?
MediHelp rates the interaction as minor. Citalopram and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may increase citalopram exposure; its effect on CYP2C19 is opposite (induction), so net effect is uncertain. Higher citalopram levels could raise QT and adverse effect risk.
How serious is the interaction between Citalopram and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for citalopram adverse effects or loss of efficacy during letermovir therapy. Consider an ECG in patients with additional QT risk factors.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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