Drug interactions
Citalopram + Lurasidone
Severity: Minor
Citalopram and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system and may add to sedation, dizziness and impaired psychomotor function. Lurasidone has little QT effect, so the interaction is mainly pharmacodynamic. Serotonergic and extrapyramidal effects may also be additive in some patients.
What this interaction means in plain words
Citalopram and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for sedation, akathisia and mood or movement changes during initiation and dose changes. Counsel patients about driving until response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Citalopram with Lurasidone?
MediHelp rates the interaction as minor. Citalopram and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the central nervous system and may add to sedation, dizziness and impaired psychomotor function. Lurasidone has little QT effect, so the interaction is mainly pharmacodynamic. Serotonergic and extrapyramidal effects may also be additive in some patients.
How serious is the interaction between Citalopram and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and mood or movement changes during initiation and dose changes. Counsel patients about driving until response is known.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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