Drug interactions
Citalopram + Metoprolol
Severity: Minor
Citalopram and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram is a weak CYP2D6 inhibitor and may modestly raise metoprolol concentrations. The clinical effect is generally small, but bradycardia and reduced cardioselectivity are possible.
What this interaction means in plain words
Citalopram and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6 by citalopram reduces metoprolol metabolism.
What to do
Monitor heart rate and blood pressure after starting citalopram, and reduce the metoprolol dose if bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Metoprolol?
MediHelp rates the interaction as minor. Citalopram and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citalopram is a weak CYP2D6 inhibitor and may modestly raise metoprolol concentrations. The clinical effect is generally small, but bradycardia and reduced cardioselectivity are possible.
How serious is the interaction between Citalopram and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting citalopram, and reduce the metoprolol dose if bradycardia occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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