Drug interactions
Fingolimod + Osilodrostat
Severity: Major
Fingolimod and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat prolongs the QT interval and fingolimod causes bradycardia, which is a risk factor for torsades de pointes. Using them together may increase arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Fingolimod and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, with fingolimod-induced bradycardia increasing the proarrhythmic risk.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc after starting or changing doses. Consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Fingolimod with Osilodrostat?
MediHelp rates the interaction as major. Fingolimod and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osilodrostat prolongs the QT interval and fingolimod causes bradycardia, which is a risk factor for torsades de pointes. Using them together may increase arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Fingolimod and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc after starting or changing doses. Consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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