Drug interactions
Citalopram + Osimertinib
Severity: Moderate
Citalopram and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and citalopram has a well-established dose-related QT effect. Combining them may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Citalopram and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform periodic ECG monitoring and check electrolytes, correcting potassium and magnesium abnormalities. Consider reducing citalopram or changing therapy if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Citalopram with Osimertinib?
MediHelp rates the interaction as moderate. Citalopram and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and citalopram has a well-established dose-related QT effect. Combining them may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Citalopram and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check electrolytes, correcting potassium and magnesium abnormalities. Consider reducing citalopram or changing therapy if the QTc becomes markedly prolonged.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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