Drug interactions
Citalopram + Ribociclib
Severity: Major
Citalopram and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes dose-dependent QT prolongation and inhibits CYP3A4, which contributes to citalopram metabolism. The combination can raise citalopram exposure and add to QT effects, increasing the risk of torsades de pointes.
What this interaction means in plain words
Citalopram and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with ribociclib CYP3A4 inhibition possibly raising citalopram levels.
What to do
Avoid if possible and consider sertraline or another antidepressant with less QT effect. If used together, monitor the ECG and electrolytes at baseline and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Citalopram with Ribociclib?
MediHelp rates the interaction as major. Citalopram and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes dose-dependent QT prolongation and inhibits CYP3A4, which contributes to citalopram metabolism. The combination can raise citalopram exposure and add to QT effects, increasing the risk of torsades de pointes.
How serious is the interaction between Citalopram and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and consider sertraline or another antidepressant with less QT effect. If used together, monitor the ECG and electrolytes at baseline and during treatment.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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