Drug interactions
Citalopram + Selinexor
Severity: Moderate
Citalopram and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and citalopram can add to central nervous system adverse effects. No specific pharmacokinetic interaction is established, so the concern is additive central effects.
What this interaction means in plain words
Citalopram and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Possible additive CNS adverse effects; no defined pharmacokinetic mechanism.
What to do
Monitor for dizziness, confusion and falls, particularly during selinexor initiation. Counsel the patient on fall prevention and reduce doses if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Citalopram with Selinexor?
MediHelp rates the interaction as moderate. Citalopram and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and citalopram can add to central nervous system adverse effects. No specific pharmacokinetic interaction is established, so the concern is additive central effects.
How serious is the interaction between Citalopram and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls, particularly during selinexor initiation. Counsel the patient on fall prevention and reduce doses if neurological toxicity develops.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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