Drug interactions
Citalopram + Solifenacin
Severity: Moderate
Citalopram and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram causes dose-dependent QT prolongation and solifenacin has a smaller, label-noted QT effect. Combined use may increase the risk of arrhythmia, especially in older patients or those with hypokalemia or bradycardia.
What this interaction means in plain words
Citalopram and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Keep citalopram at or below the maximum labeled dose for the patient's age and hepatic function. Check ECG and electrolytes in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Citalopram and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Solifenacin
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Solifenacin?
MediHelp rates the interaction as moderate. Citalopram and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram causes dose-dependent QT prolongation and solifenacin has a smaller, label-noted QT effect. Combined use may increase the risk of arrhythmia, especially in older patients or those with hypokalemia or bradycardia.
How serious is the interaction between Citalopram and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep citalopram at or below the maximum labeled dose for the patient's age and hepatic function. Check ECG and electrolytes in patients with additional risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
