Drug interactions
Citalopram + Tazemetostat
Severity: Minor
Citalopram and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer, which may slightly reduce citalopram concentrations. Because CYP3A4 is only a secondary route for citalopram, the effect is probably small.
What this interaction means in plain words
Citalopram and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, modestly increasing citalopram metabolism.
What to do
Monitor for reduced antidepressant response and adjust citalopram dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Citalopram with Tazemetostat?
MediHelp rates the interaction as minor. Citalopram and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer, which may slightly reduce citalopram concentrations. Because CYP3A4 is only a secondary route for citalopram, the effect is probably small.
How serious is the interaction between Citalopram and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and adjust citalopram dose if needed.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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