Drug interactions
Citalopram + Tipranavir
Severity: Moderate
Citalopram and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may raise citalopram concentrations because of CYP3A4 and CYP2C19 involvement in its metabolism. Higher exposure increases dose-related QT prolongation and serotonergic adverse effects.
What this interaction means in plain words
Citalopram and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C19) by ritonavir-boosted tipranavir reduces citalopram clearance, though tipranavir also has inducing effects so the net result is variable.
What to do
Start citalopram at a low dose and titrate cautiously, staying within the labeled maximum. Monitor ECG and for serotonergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Citalopram with Tipranavir?
MediHelp rates the interaction as moderate. Citalopram and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, may raise citalopram concentrations because of CYP3A4 and CYP2C19 involvement in its metabolism. Higher exposure increases dose-related QT prolongation and serotonergic adverse effects.
How serious is the interaction between Citalopram and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start citalopram at a low dose and titrate cautiously, staying within the labeled maximum. Monitor ECG and for serotonergic effects.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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