Drug interactions
Citalopram + Tizanidine
Severity: Minor
Citalopram and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram has weak CYP1A2 inhibiting activity at most, so any rise in tizanidine exposure is unlikely to be large, though both drugs can cause drowsiness and tizanidine can lower blood pressure. Combined use may add to psychomotor impairment and, rarely, QT effects with hypotension or bradycardia could matter.
What this interaction means in plain words
Citalopram and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Possible weak pharmacokinetic effect on CYP1A2 metabolism of tizanidine plus additive CNS effects; the mechanism is not firmly established.
What to do
No routine adjustment is needed; monitor for excess sedation, hypotension or bradycardia and reduce tizanidine if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Tizanidine?
MediHelp rates the interaction as minor. Citalopram and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citalopram has weak CYP1A2 inhibiting activity at most, so any rise in tizanidine exposure is unlikely to be large, though both drugs can cause drowsiness and tizanidine can lower blood pressure. Combined use may add to psychomotor impairment and, rarely, QT effects with hypotension or bradycardia could matter.
How serious is the interaction between Citalopram and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for excess sedation, hypotension or bradycardia and reduce tizanidine if these occur.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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