Drug interactions
Citalopram + Torsemide
Severity: Moderate
Citalopram and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both loop diuretics and SSRIs can lower serum sodium, so combined use raises the risk of hyponatremia, particularly in older adults. Hypokalemia and hypomagnesemia from the diuretic also add to citalopram's QT-prolonging risk.
What this interaction means in plain words
Citalopram and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Torsemide belongs to Cardiovascular.
Why it happens
Additive hyponatremia through diuretic sodium loss and SSRI-associated SIADH; diuretic electrolyte loss may potentiate QT prolongation.
What to do
Check sodium, potassium and magnesium at baseline and after starting the combination, and correct deficits; consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Torsemide?
MediHelp rates the interaction as moderate. Citalopram and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both loop diuretics and SSRIs can lower serum sodium, so combined use raises the risk of hyponatremia, particularly in older adults. Hypokalemia and hypomagnesemia from the diuretic also add to citalopram's QT-prolonging risk.
How serious is the interaction between Citalopram and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sodium, potassium and magnesium at baseline and after starting the combination, and correct deficits; consider an ECG in patients with other QT risk factors.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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