Drug interactions
Cladribine + Denosumab
Severity: Moderate
Cladribine and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab labeling warns of serious infections in patients with impaired immunity. Cladribine causes lymphopenia and immunosuppression, which adds to infection risk.
What this interaction means in plain words
Cladribine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Denosumab belongs to Oncology.
Why it happens
Additive immunosuppression: denosumab modulates RANKL signalling and cladribine depletes lymphocytes.
What to do
Monitor lymphocyte counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Frequently asked questions
Can I take Cladribine with Denosumab?
MediHelp rates the interaction as moderate. Cladribine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections in patients with impaired immunity. Cladribine causes lymphopenia and immunosuppression, which adds to infection risk.
How serious is the interaction between Cladribine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphocyte counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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