Drug interactions
Cladribine + Trastuzumab deruxtecan
Severity: Moderate
Cladribine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the risk of severe neutropenia and infection.
What this interaction means in plain words
Cladribine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive effects.
What to do
Monitor complete blood counts and for infection frequently. Delay or reduce doses for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Cladribine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Cladribine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the risk of severe neutropenia and infection.
How serious is the interaction between Cladribine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection frequently. Delay or reduce doses for severe neutropenia.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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