Drug interactions
Clarithromycin + Diazepam intranasal
Severity: Moderate
Clarithromycin and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may slow diazepam elimination and increase its sedative and respiratory depressant effects. This is relevant for rescue use of intranasal diazepam in seizures.
What this interaction means in plain words
Clarithromycin and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4, which contributes to diazepam metabolism.
What to do
Monitor for excessive sedation and respiratory depression after dosing. Be aware that recovery may be prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Diazepam intranasal?
MediHelp rates the interaction as moderate. Clarithromycin and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may slow diazepam elimination and increase its sedative and respiratory depressant effects. This is relevant for rescue use of intranasal diazepam in seizures.
How serious is the interaction between Clarithromycin and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression after dosing. Be aware that recovery may be prolonged.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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