Drug interactions
Clarithromycin + Ergoloid mesylates
Severity: Major
Clarithromycin and Ergoloid mesylates: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise ergoloid concentrations and increase the risk of ergot-type toxicity such as vasospasm. Ergoloids are less vasoconstrictive than other ergots, but the class warning against strong CYP3A4 inhibitors applies.
What this interaction means in plain words
Clarithromycin and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Clarithromycin inhibits CYP3A4, reducing clearance of ergoloid mesylates.
What to do
Avoid the combination and use an alternative antibiotic such as azithromycin; if exposure occurs, monitor for ischemic symptoms, nausea and paresthesia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Ergoloid mesylates?
MediHelp rates the interaction as major. Clarithromycin and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may raise ergoloid concentrations and increase the risk of ergot-type toxicity such as vasospasm. Ergoloids are less vasoconstrictive than other ergots, but the class warning against strong CYP3A4 inhibitors applies.
How serious is the interaction between Clarithromycin and Ergoloid mesylates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antibiotic such as azithromycin; if exposure occurs, monitor for ischemic symptoms, nausea and paresthesia.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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