Drug interactions
Clarithromycin + Estradiol vaginal
Severity: Minor
Clarithromycin and Estradiol vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase systemic estradiol exposure, but vaginal products bypass first-pass metabolism and give low systemic levels, so the effect is expected to be small.
What this interaction means in plain words
Clarithromycin and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Clarithromycin inhibits CYP3A4-mediated estradiol metabolism.
What to do
No adjustment is generally needed. Advise the patient to report breast tenderness or abnormal bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Estradiol vaginal?
MediHelp rates the interaction as minor. Clarithromycin and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may increase systemic estradiol exposure, but vaginal products bypass first-pass metabolism and give low systemic levels, so the effect is expected to be small.
How serious is the interaction between Clarithromycin and Estradiol vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed. Advise the patient to report breast tenderness or abnormal bleeding.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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