Drug interactions
Clarithromycin + Estrogens esterified
Severity: Minor
Clarithromycin and Estrogens esterified: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise circulating estrogen levels. This could increase estrogenic adverse effects such as breast tenderness, nausea and fluid retention.
What this interaction means in plain words
Clarithromycin and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Clarithromycin inhibits CYP3A4, which contributes to estrogen metabolism.
What to do
No routine adjustment is required. Monitor for estrogen-related adverse effects during longer courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Estrogens esterified?
MediHelp rates the interaction as minor. Clarithromycin and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may raise circulating estrogen levels. This could increase estrogenic adverse effects such as breast tenderness, nausea and fluid retention.
How serious is the interaction between Clarithromycin and Estrogens esterified?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for estrogen-related adverse effects during longer courses.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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