Drug interactions
Clarithromycin + Estropipate
Severity: Minor
Clarithromycin and Estropipate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may modestly raise estrogen concentrations, potentially increasing estrogenic effects such as breast tenderness, fluid retention or nausea. The effect is usually not serious.
What this interaction means in plain words
Clarithromycin and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Clarithromycin inhibits CYP3A4, which contributes to estrogen metabolism.
What to do
No routine change is needed for a short antibiotic course. Monitor for estrogen excess and review the dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Estropipate?
MediHelp rates the interaction as minor. Clarithromycin and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may modestly raise estrogen concentrations, potentially increasing estrogenic effects such as breast tenderness, fluid retention or nausea. The effect is usually not serious.
How serious is the interaction between Clarithromycin and Estropipate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for a short antibiotic course. Monitor for estrogen excess and review the dose if symptoms occur.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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