Drug interactions
clarithromycin + fentanyl
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ fentanyl → respiratory depression.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid or use minimal doses with monitoring.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with fentanyl?
The interaction is rated: Major. ↑ fentanyl → respiratory depression.
How serious is the interaction between clarithromycin and fentanyl?
The interaction is rated: Major. Evidence level: High.
How is the interaction between clarithromycin and fentanyl managed?
Avoid or use minimal doses with monitoring.
Why do clarithromycin and fentanyl interact?
CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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