Drug interactions
Clarithromycin + Hydroxyprogesterone caproate
Severity: Minor
Clarithromycin and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so clarithromycin may increase its concentrations. Clinical consequences are poorly characterized and likely modest.
What this interaction means in plain words
Clarithromycin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Predicted CYP3A4 inhibition reducing hydroxyprogesterone metabolism.
What to do
No dose adjustment is generally required; monitor for increased progestogenic adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Clarithromycin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is partly metabolized by CYP3A4, so clarithromycin may increase its concentrations. Clinical consequences are poorly characterized and likely modest.
How serious is the interaction between Clarithromycin and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for increased progestogenic adverse effects during prolonged co-therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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