Drug interactions
Clarithromycin + Infigratinib
Severity: Major
Clarithromycin and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure. This may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Clarithromycin and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition reduces infigratinib clearance.
What to do
Avoid the combination and use a non-inhibiting antibiotic. If unavoidable, monitor serum phosphate and for toxicity and reduce the infigratinib dose as labeled.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Infigratinib?
MediHelp rates the interaction as major. Clarithromycin and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib is metabolized mainly by CYP3A4, so clarithromycin can increase its exposure. This may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Clarithromycin and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inhibiting antibiotic. If unavoidable, monitor serum phosphate and for toxicity and reduce the infigratinib dose as labeled.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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