Drug interactions
Clarithromycin + Inotuzumab
Severity: Moderate
Clarithromycin and Inotuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or underlying cardiac disease.
What this interaction means in plain words
Clarithromycin and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Use a non-QT-prolonging antibiotic if possible. Otherwise obtain ECG and electrolytes before starting and periodically during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Inotuzumab?
MediHelp rates the interaction as moderate. Clarithromycin and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. The risk is greater with electrolyte abnormalities or underlying cardiac disease.
How serious is the interaction between Clarithromycin and Inotuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic if possible. Otherwise obtain ECG and electrolytes before starting and periodically during therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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