Drug interactions
Clarithromycin + Isradipine
Severity: Moderate
Clarithromycin and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and may raise isradipine levels, causing hypotension, edema or tachycardia. Isradipine is not a recognized QT-prolonging drug, so the legacy QT rationale is weak.
What this interaction means in plain words
Clarithromycin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces first-pass and systemic metabolism of isradipine.
What to do
Monitor blood pressure and heart rate when starting or stopping clarithromycin, and reduce the isradipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Isradipine?
MediHelp rates the interaction as moderate. Clarithromycin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and may raise isradipine levels, causing hypotension, edema or tachycardia. Isradipine is not a recognized QT-prolonging drug, so the legacy QT rationale is weak.
How serious is the interaction between Clarithromycin and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping clarithromycin, and reduce the isradipine dose if hypotension occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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