Drug interactions
Clarithromycin + Mometasone inhaled
Severity: Moderate
Clarithromycin and Mometasone inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mometasone is cleared by CYP3A4, and clarithromycin can increase its systemic exposure. This may cause systemic corticosteroid effects, including adrenal suppression and Cushingoid features, especially with prolonged use.
What this interaction means in plain words
Clarithromycin and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by clarithromycin reduces mometasone clearance.
What to do
For short clarithromycin courses, monitor for systemic corticosteroid effects. With long-term coadministration, consider a less CYP3A4-dependent corticosteroid such as beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Mometasone inhaled?
MediHelp rates the interaction as moderate. Clarithromycin and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mometasone is cleared by CYP3A4, and clarithromycin can increase its systemic exposure. This may cause systemic corticosteroid effects, including adrenal suppression and Cushingoid features, especially with prolonged use.
How serious is the interaction between Clarithromycin and Mometasone inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For short clarithromycin courses, monitor for systemic corticosteroid effects. With long-term coadministration, consider a less CYP3A4-dependent corticosteroid such as beclomethasone.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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