Drug interactions
Clarithromycin + Mometasone intranasal
Severity: Minor
Clarithromycin and Mometasone intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal mometasone has very low systemic bioavailability, so any increase from clarithromycin's CYP3A4 inhibition is unlikely to be clinically relevant for short-term use. Systemic corticosteroid effects are theoretically possible with prolonged coadministration.
What this interaction means in plain words
Clarithromycin and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by clarithromycin could slightly raise systemic mometasone exposure.
What to do
No action is needed for typical short courses. Watch for signs of systemic corticosteroid excess if both drugs are used over a prolonged period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Mometasone intranasal?
MediHelp rates the interaction as minor. Clarithromycin and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal mometasone has very low systemic bioavailability, so any increase from clarithromycin's CYP3A4 inhibition is unlikely to be clinically relevant for short-term use. Systemic corticosteroid effects are theoretically possible with prolonged coadministration.
How serious is the interaction between Clarithromycin and Mometasone intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for typical short courses. Watch for signs of systemic corticosteroid excess if both drugs are used over a prolonged period.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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