Drug interactions
Clarithromycin + Neomycin po
Severity: Minor
Clarithromycin and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin has minimal systemic absorption, so P-gp inhibition by clarithromycin is unlikely to cause meaningful systemic exposure. No clear clinically significant interaction is established.
What this interaction means in plain words
Clarithromycin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by clarithromycin could slightly increase neomycin absorption.
What to do
No specific action is needed. Monitor renal function and hearing if neomycin is used long-term or in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Neomycin po?
MediHelp rates the interaction as minor. Clarithromycin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin has minimal systemic absorption, so P-gp inhibition by clarithromycin is unlikely to cause meaningful systemic exposure. No clear clinically significant interaction is established.
How serious is the interaction between Clarithromycin and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor renal function and hearing if neomycin is used long-term or in renal impairment.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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