Drug interactions
Clarithromycin + Nirogacestat
Severity: Major
Clarithromycin and Nirogacestat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase nirogacestat exposure, increasing the risk of diarrhea, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Clarithromycin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Nirogacestat belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition decreases nirogacestat metabolism.
What to do
Avoid the combination and use a non-CYP3A-inhibiting antibiotic. If unavoidable, follow labeled dose reduction and monitor liver tests and GI tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Clarithromycin with Nirogacestat?
MediHelp rates the interaction as major. Clarithromycin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may increase nirogacestat exposure, increasing the risk of diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Clarithromycin and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A-inhibiting antibiotic. If unavoidable, follow labeled dose reduction and monitor liver tests and GI tolerability.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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