Drug interactions
Clarithromycin + Nitrendipine
Severity: Moderate
Clarithromycin and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine is a CYP3A4 substrate, and clarithromycin may raise its levels, causing hypotension, flushing, headache and peripheral edema. Similar interactions with other dihydropyridines suggest a clinically relevant effect.
What this interaction means in plain words
Clarithromycin and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by clarithromycin reduces nitrendipine metabolism.
What to do
Monitor blood pressure and heart rate, and reduce the nitrendipine dose if hypotension or edema occurs. Consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Nitrendipine?
MediHelp rates the interaction as moderate. Clarithromycin and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrendipine is a CYP3A4 substrate, and clarithromycin may raise its levels, causing hypotension, flushing, headache and peripheral edema. Similar interactions with other dihydropyridines suggest a clinically relevant effect.
How serious is the interaction between Clarithromycin and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the nitrendipine dose if hypotension or edema occurs. Consider an alternative antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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