Drug interactions
Clarithromycin + Paclitaxel protein bound
Severity: Moderate
Clarithromycin and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and P-glycoprotein, both of which contribute to paclitaxel handling, so exposure to paclitaxel may rise. This could increase myelosuppression and peripheral neuropathy.
What this interaction means in plain words
Clarithromycin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux by clarithromycin reduces paclitaxel clearance.
What to do
Where possible use a non-inhibiting antibiotic such as azithromycin. If combined, monitor neutrophil counts and neuropathy and reduce the paclitaxel dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Clarithromycin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and P-glycoprotein, both of which contribute to paclitaxel handling, so exposure to paclitaxel may rise. This could increase myelosuppression and peripheral neuropathy.
How serious is the interaction between Clarithromycin and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible use a non-inhibiting antibiotic such as azithromycin. If combined, monitor neutrophil counts and neuropathy and reduce the paclitaxel dose as needed.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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