Drug interactions
clarithromycin + pimozide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked QT prolongation → torsades risk.
Mechanism of action
CYP3A4 inhibition + additive QT.
Clinical management
Contraindicated; choose non-macrolide antibiotic.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with pimozide?
The interaction is rated: Contraindicated. Marked QT prolongation → torsades risk.
How serious is the interaction between clarithromycin and pimozide?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between clarithromycin and pimozide managed?
Contraindicated; choose non-macrolide antibiotic.
Why do clarithromycin and pimozide interact?
CYP3A4 inhibition + additive QT.
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