Drug interactions
Clarithromycin + Progesterone micronized
Severity: Moderate
Clarithromycin and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise exposure to oral micronized progesterone, which undergoes extensive CYP3A4 first-pass metabolism. This could increase sedation, dizziness and other progestogenic effects.
What this interaction means in plain words
Clarithromycin and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits intestinal and hepatic CYP3A4, decreasing progesterone metabolism.
What to do
Monitor for excessive drowsiness, dizziness and progestogenic adverse effects during clarithromycin therapy. Consider dose reduction or a different antibiotic if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Progesterone micronized?
MediHelp rates the interaction as moderate. Clarithromycin and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise exposure to oral micronized progesterone, which undergoes extensive CYP3A4 first-pass metabolism. This could increase sedation, dizziness and other progestogenic effects.
How serious is the interaction between Clarithromycin and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and progestogenic adverse effects during clarithromycin therapy. Consider dose reduction or a different antibiotic if symptoms occur.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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