Drug interactions
Clarithromycin + Progesterone natural
Severity: Moderate
Clarithromycin and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase concentrations of natural progesterone, particularly after oral dosing, potentially causing sedation, dizziness and other progestogenic effects.
What this interaction means in plain words
Clarithromycin and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4-mediated progesterone metabolism.
What to do
Monitor for increased progestogenic effects while on clarithromycin and reduce the progesterone dose if they occur. Consider azithromycin as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Progesterone natural?
MediHelp rates the interaction as moderate. Clarithromycin and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase concentrations of natural progesterone, particularly after oral dosing, potentially causing sedation, dizziness and other progestogenic effects.
How serious is the interaction between Clarithromycin and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased progestogenic effects while on clarithromycin and reduce the progesterone dose if they occur. Consider azithromycin as an alternative.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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