Drug interactions
Clarithromycin + Quazepam
Severity: Moderate
Clarithromycin and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is metabolized by CYP3A4 and other enzymes, so clarithromycin can raise its levels. This may deepen sedation, impair psychomotor performance and add to respiratory depression risk.
What this interaction means in plain words
Clarithromycin and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4 metabolism of quazepam.
What to do
Monitor for excess sedation and consider lowering the quazepam dose during clarithromycin therapy, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Quazepam?
MediHelp rates the interaction as moderate. Clarithromycin and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is metabolized by CYP3A4 and other enzymes, so clarithromycin can raise its levels. This may deepen sedation, impair psychomotor performance and add to respiratory depression risk.
How serious is the interaction between Clarithromycin and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the quazepam dose during clarithromycin therapy, especially in older patients.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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