Drug interactions
Clarithromycin + Rabeprazole
Severity: Minor
Clarithromycin and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may modestly raise rabeprazole exposure and rabeprazole may raise clarithromycin levels. This combination is routinely used in H. pylori regimens and is generally well tolerated.
What this interaction means in plain words
Clarithromycin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Clarithromycin inhibits CYP3A4 and rabeprazole has minor effects on clarithromycin clearance, producing small mutual increases in exposure.
What to do
No dose adjustment is needed in standard H. pylori regimens; monitor for gastrointestinal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Rabeprazole?
MediHelp rates the interaction as minor. Clarithromycin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may modestly raise rabeprazole exposure and rabeprazole may raise clarithromycin levels. This combination is routinely used in H. pylori regimens and is generally well tolerated.
How serious is the interaction between Clarithromycin and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed in standard H. pylori regimens; monitor for gastrointestinal adverse effects.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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