Drug interactions
Clarithromycin + Sacubitril / valsartan
Severity: Minor
Clarithromycin and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is an OATP1B1 substrate, and clarithromycin may inhibit hepatic uptake transporters. Any increase in exposure is expected to be small and could slightly increase hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Clarithromycin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of hepatic uptake transport of valsartan; not firmly established.
What to do
No dose change is usually needed; monitor blood pressure, potassium and renal function as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Clarithromycin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is an OATP1B1 substrate, and clarithromycin may inhibit hepatic uptake transporters. Any increase in exposure is expected to be small and could slightly increase hypotension, hyperkalemia or renal effects.
How serious is the interaction between Clarithromycin and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure, potassium and renal function as routine.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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