Drug interactions
Clarithromycin + Temocillin
Severity: Minor
Clarithromycin and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A bacteriostatic macrolide may theoretically blunt the bactericidal effect of a beta-lactam, but clinical evidence of meaningful antagonism is limited.
What this interaction means in plain words
Clarithromycin and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism between a protein synthesis inhibitor and a cell wall active beta-lactam.
What to do
No routine action is required; review clinical response in serious infections and avoid unnecessary dual therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Temocillin?
MediHelp rates the interaction as minor. Clarithromycin and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A bacteriostatic macrolide may theoretically blunt the bactericidal effect of a beta-lactam, but clinical evidence of meaningful antagonism is limited.
How serious is the interaction between Clarithromycin and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; review clinical response in serious infections and avoid unnecessary dual therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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