Drug interactions
Clarithromycin + Tezacaftor
Severity: Moderate
Clarithromycin and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin, a strong CYP3A4 inhibitor, increases tezacaftor exposure (given with ivacaftor). The higher exposure may increase adverse effects, so the regimen is adjusted.
What this interaction means in plain words
Clarithromycin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces metabolism of tezacaftor.
What to do
Reduce the tezacaftor/ivacaftor dosing frequency to the reduced schedule in its labeling while clarithromycin is taken. Return to the usual dosing after clarithromycin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Tezacaftor?
MediHelp rates the interaction as moderate. Clarithromycin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin, a strong CYP3A4 inhibitor, increases tezacaftor exposure (given with ivacaftor). The higher exposure may increase adverse effects, so the regimen is adjusted.
How serious is the interaction between Clarithromycin and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the tezacaftor/ivacaftor dosing frequency to the reduced schedule in its labeling while clarithromycin is taken. Return to the usual dosing after clarithromycin is stopped.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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