Drug interactions
Clarithromycin + Tiagabine
Severity: Moderate
Clarithromycin and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase tiagabine concentrations, potentially causing dizziness, somnolence, confusion and in some cases seizures.
What this interaction means in plain words
Clarithromycin and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4, the main pathway of tiagabine metabolism.
What to do
Monitor for CNS adverse effects and reduce the tiagabine dose if they occur. Consider azithromycin or another antibiotic that does not inhibit CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Tiagabine?
MediHelp rates the interaction as moderate. Clarithromycin and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase tiagabine concentrations, potentially causing dizziness, somnolence, confusion and in some cases seizures.
How serious is the interaction between Clarithromycin and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and reduce the tiagabine dose if they occur. Consider azithromycin or another antibiotic that does not inhibit CYP3A4.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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