Drug interactions
Clarithromycin + Triamcinolone acetonide injectable
Severity: Moderate
Clarithromycin and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin can increase systemic triamcinolone exposure, leading to corticosteroid excess such as Cushing's syndrome and adrenal suppression. Cases have been described with other CYP3A4-inhibiting macrolide or antiretroviral combinations and depot corticosteroids.
What this interaction means in plain words
Clarithromycin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4-mediated metabolism of triamcinolone.
What to do
Consider an alternative antibiotic such as azithromycin, particularly with repeated or high-dose injections. If combined, monitor for Cushing features, hyperglycemia and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Clarithromycin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin can increase systemic triamcinolone exposure, leading to corticosteroid excess such as Cushing's syndrome and adrenal suppression. Cases have been described with other CYP3A4-inhibiting macrolide or antiretroviral combinations and depot corticosteroids.
How serious is the interaction between Clarithromycin and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic such as azithromycin, particularly with repeated or high-dose injections. If combined, monitor for Cushing features, hyperglycemia and adrenal suppression.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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