Drug interactions
Clarithromycin + Tropisetron
Severity: Moderate
Clarithromycin and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Co-administration may add to arrhythmic risk, especially with electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Clarithromycin and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check ECG and correct potassium and magnesium before using both drugs. Monitor for palpitations or syncope, or use an alternative antiemetic or antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Tropisetron?
MediHelp rates the interaction as moderate. Clarithromycin and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Co-administration may add to arrhythmic risk, especially with electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Clarithromycin and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before using both drugs. Monitor for palpitations or syncope, or use an alternative antiemetic or antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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