Drug interactions
Clarithromycin + Typhoid vaccine live
Severity: Moderate
Clarithromycin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics with activity against Salmonella Typhi can kill the live attenuated organism in oral typhoid vaccine and reduce the immune response. Clarithromycin has some activity against enteric organisms, so vaccine take may be impaired.
What this interaction means in plain words
Clarithromycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial action may reduce viability of the live attenuated vaccine strain.
What to do
Give the oral live typhoid vaccine at least 3 days after the last antibiotic dose and avoid starting antibiotics for several days after the vaccine. Use the inactivated injectable vaccine if antibiotic therapy cannot be delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Clarithromycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics with activity against Salmonella Typhi can kill the live attenuated organism in oral typhoid vaccine and reduce the immune response. Clarithromycin has some activity against enteric organisms, so vaccine take may be impaired.
How serious is the interaction between Clarithromycin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral live typhoid vaccine at least 3 days after the last antibiotic dose and avoid starting antibiotics for several days after the vaccine. Use the inactivated injectable vaccine if antibiotic therapy cannot be delayed.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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