Drug interactions
Clarithromycin + Ulipristal
Severity: Moderate
Clarithromycin and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is metabolized by CYP3A4, so clarithromycin may increase its exposure. For single-dose emergency contraception the clinical significance is probably small, though the labeling advises against use with strong inhibitors.
What this interaction means in plain words
Clarithromycin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clarithromycin inhibits CYP3A4 metabolism of ulipristal.
What to do
For single-dose emergency contraception, monitor for adverse effects; for repeated dosing, consider an alternative contraceptive method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Ulipristal?
MediHelp rates the interaction as moderate. Clarithromycin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is metabolized by CYP3A4, so clarithromycin may increase its exposure. For single-dose emergency contraception the clinical significance is probably small, though the labeling advises against use with strong inhibitors.
How serious is the interaction between Clarithromycin and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For single-dose emergency contraception, monitor for adverse effects; for repeated dosing, consider an alternative contraceptive method.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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