Drug interactions
Clarithromycin + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Clarithromycin and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise systemic exposure to vilanterol and fluticasone furoate, enhancing beta-agonist cardiovascular effects and corticosteroid systemic effects. Clarithromycin also prolongs the QT interval.
What this interaction means in plain words
Clarithromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces clearance of vilanterol and fluticasone furoate, with additive QT effects.
What to do
Consider an alternative antibiotic where feasible. If combined, monitor heart rate, ECG in at-risk patients and signs of systemic corticosteroid excess with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Clarithromycin and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise systemic exposure to vilanterol and fluticasone furoate, enhancing beta-agonist cardiovascular effects and corticosteroid systemic effects. Clarithromycin also prolongs the QT interval.
How serious is the interaction between Clarithromycin and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic where feasible. If combined, monitor heart rate, ECG in at-risk patients and signs of systemic corticosteroid excess with prolonged use.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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