Drug interactions
Clarithromycin + Zanubrutinib
Severity: Moderate
Clarithromycin and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises zanubrutinib exposure through CYP3A4 inhibition. Higher levels may increase the risk of bleeding, cytopenias, infection and arrhythmia such as atrial fibrillation.
What this interaction means in plain words
Clarithromycin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces zanubrutinib first-pass and systemic metabolism.
What to do
Reduce the zanubrutinib dose per labeling while clarithromycin is used, and monitor blood counts and for bleeding. Resume the previous dose after clarithromycin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Clarithromycin with Zanubrutinib?
MediHelp rates the interaction as moderate. Clarithromycin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin raises zanubrutinib exposure through CYP3A4 inhibition. Higher levels may increase the risk of bleeding, cytopenias, infection and arrhythmia such as atrial fibrillation.
How serious is the interaction between Clarithromycin and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zanubrutinib dose per labeling while clarithromycin is used, and monitor blood counts and for bleeding. Resume the previous dose after clarithromycin is stopped.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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